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In this article, we take an in-depth look into the endocannabinoid system (ECS), and the parts that make up this newly discovered body system. What are cannabinoids? What are cannabinoid receptors? Where are these receptors located in the body? And how do cannabinoids interact with these receptors, providing specific health benefits? Keep reading for these answers and more.
You may know that the human body contains numerous receptors that respond to light, pressure, temperature, and chemicals to create physiological reactions that either encourage or hinder growth, healing, and renewal. But, did you realize that our bodies actually contain receptors specifically for cannabinoids?
We possess an endocannabinoid system with two types of CB receptors and several other receptors that interact with cannabinoids. Discover how your body works with these cool little chemicals.
This system not only receives these compounds from sources like full spectrum CBD oil but also produces its own along with enzymes that synthesize and degrade endocannabinoids. Yes, we self-produce cannabinoids, making them more natural than originally understood!
It makes perfect sense that those from hemp and marijuana provide many healing effects with little to no harm. Research continues to reveal the therapeutic potential of the endocannabinoid system.
Within this system, our brain produces Anandamide. It is one endocannabinoid, which kindles nerve cell production, triggers the reward center of the brain, increases happiness, and declutters our memory bank. Some people do not naturally create enough of this important compound, creating a real need for outside help.
Luckily the receptors will accept outside help from full spectrum CBD oil and other cannabinoid-rich sources. Let’s take a look at the receptors that play an integral role in helping the body function optimally and remedy many different ailments.
The nervous system and regions of the brain, including the hippocampus, cerebellum, and cerebrum, contain numerous CB1 receptors. Organs, such as the liver, kidneys, and lungs also hold some.
Endocannabinoids and outside sources bind to these areas. When bound, they affect pain control, appetite, cognition, and mood. Due to the high population in the brain, compounds that bind directly to CB1 receptors tend to produce a psychoactive effect.
For instance, THC, from the Cannabis plant, binds here to lower the user’s perception of pain, increase their appetite, and improve their mood. It’s also responsible for altering their cognition to make them feel stoned.
This simply touches the surface of the incredible reactions caused by substances binding to these receptors. CB1 receptors offer therapeutic importance for treating:
The potential high that frightened a government into criminalizing the marijuana plant may only be a minor side effect compared to the benefits researchers continue to find associated with this particular receptor.
Throughout the immune system, on immune cells, tonsils, the spleen, and along the gastrointestinal tract, you will find these amazing reaction sites. CB2 receptors work in conjunction with our bodies to heal and maintain equilibrium.
Cannabinoids, such as CBD, stimulate to this network. Though some act directly, CBD is thought to possess the versatility to indirectly stimulate both cannabinoid receptors, as well as a host of other biologically important areas in the body.
When compounds from full spectrum CBD oil trigger these receptors, research indicates that they create a response that reduces inflammation and relieves pain. Due to its profound impact on the CB2 receptors, CBD shows promise for treating:
To trigger the effects of only these areas and not CB1 receptors, try a pure CBD oil.
Many cannabinoids signal the production of neurotransmitters that balance us and keep us feeling positively good.
CBD and other cannabinoids activate MT receptors, which prompt the pineal gland to produce melatonin. This neurotransmitter keeps the circadian rhythm cycling properly. Meaning, it helps you fall asleep easier, stay asleep for a full cycle, and therefore feel better.
When triggered by the endocannabinoid system, these G protein-coupled receptors generate powerful neurotransmitter that produces both excitatory and inhibitory effects on the body. Serotonin aids in:
Doctors link the lack of serotonin to a number of disorders, including clinical depression and anxiety. This explains why both THC and CBD seem to profoundly affect these conditions.
Vanilloid receptors help to mediate the therapeutic effects of cannabinoids, such as anandamide and CBD, when they act directly on associated ion channels. As you might have guessed, these receptors also accept active compounds found in the vanilla bean, triggering therapeutic effects that make it an ancient medicine.
TRPV1 receptors regulate body temperature, inflammation, and pain perception. This may provide comfort for fever, injury, inflammatory conditions, and headaches.
This receptor found widely in the brain and mostly concentrated in the cerebellum, is referred to as an orphan receptor, because scientists suspect that it belongs to a larger family of receptors. When activated, it actually causes a host of negative effects.
Many types of cancer cells express GPR55 receptors. Scientists believe that it encourages the growth and spread of cancer cells.
It also plays a role in osteoporosis, a degenerative bone disease. Studies show that it progresses the disease by triggering bone reabsorption.
Unlike the excitatory role with the other receptors we discussed, substances like full spectrum CBD oil actually inhibit this insidious orphan receptor. They bind to block this receptor from causing insurmountable damage to the body. Researchers continue to study CBDs inhibitory effect on GPR55 receptors to see the tole it can play in fighting both cancer and osteoporosis.
Peroxisome proliferator-activated receptors reside on the nuclear envelope of a cell. These integral receptors manage genes responsible for energy metabolism and a number of metabolic functions including fat and insulin absorption.
When cannabinoids such as CBD bind to these sites, it creates a profoundly positive effect. Aside from maintaining energy homeostasis, these receptors combat major diseases that widely affect Americans.
Nuclear receptors show promise for fighting cancer. PPSARS inhibits the growth of cancer cells and even triggers tumor regression in lung cancer patients.
When activated by cannabinoids, these sites also activate gamma, which rids neurons of amyloid-beta plaque. As this plaque builds up, it impairs brain function and leads to Alzheimer’s disease. CBD’s activation of these receptors shows promise for battling this heartbreaking illness.
The current hype over cannabis is more than a trend. This plant provides compounds that show a multiplicity of therapeutic promise through the endocannabinoid system.
Shop with us at Regenefi for the purest product on the market that will activate your cannabinoid receptors.
FDA Disclaimer: The statements regarding these products are not evaluated by the Food and Drug Administration. The efficacy of these products is not confirmed by FDA-approved research. These products do not diagnose, treat, cure or prevent any disease. All information presented here is not a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other possible complications before using any product.